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Radiofrequency Induced Thermo-Chemotherapy with Mitomycin C / Epirubicin

This leaflet contains evidence-based information about Hyperthermic Mitomycin. We have consulted specialist surgeons during its preparation, so that it represents best practice in UK urology.

This leaflet contains evidence-based information about Hyperthermic Mitomycin.  We have consulted specialist surgeons during its preparation, so that it represents best practice in UK urology. 

Key Points

  • This involves having a catheter (plastic tube) passed into your bladder to instil an anti-cancer drug (Mitomycin / Epirubicin)
  • We use it for non-muscle invasive cancers, which grow in the thin layer of cells lining the bladder but do not extend into the muscle of the bladder wall
  • Treatment reduces the chance of your bladder cancer returning
  • Bladder tumours can recur during or after treatment, so follow-up bladder examinations (cystoscopies) are needed
What does the treatment involve: Please see “Treatment schedule”.

What does this procedure involve?

Instillation of an anti-cancer drug (usually Mitomycin C or Epirubicin) into your bladder, through a catheter (pictured on page 3), for aggressive, multiple or recurrent non-muscle invasive cancer of the bladder. 

What are the alternatives?

Treatment Schedule: Hyperthermic Mitomycin / Epirubicin

What happens on the day of the procedure? 

You do not need to fast, you can eat and drink as usual; however, do not drink excessive fluids, specifically tea and coffee on the day of the procedure.

On arrival in the clinic, you will be asked to pass urine which we will test for infection.  If an infection is suspected, we will send a sample to the laboratory and, depending on your symptoms, your procedure may be postponed whilst you take a course of antibiotics.

If you urine is clear, your urologist (or a member of their team) will briefly review your history and medications, and will discuss the procedure again with you to confirm your consent.

You should allow approximately 90 minutes for your first treatment.

Details of the procedure

  • We clean your genital area with an antiseptic solution and squirt an antiseptic gel, containing local anaesthetic, into your urethra (waterpipe)
  • We then pass a catheter into your bladder (pictured below) and we empty the bladder.
  • We put 50 mls of the anti-cancer drug (normally

Mitomycin C or Epirubicin) into your bladder through the catheter

  • The catheter is than connected to the Synergo system.
  • The radiofrequency antenna embedded in the catheter will heat the bladder walls.
  • The drug within the bladder constantly circulates between the bladder and the cooling chamber of the Synergo system.
  • Upon completion of 30 minutes, the drug is removed from the bladder and a newly formulated drug (50 mls of Mitomycin C or Epirubicin) is injected into the bladder via the catheter.
  • The bladder walls are heated with and the fluid in the bladder is cooled for another 30 minutes.
  • Upon completion of the treatment, the bladder is emptied and the catheter is removed.
  • on your first visit, we normally keep you in the clinic until you have passed urine but, for any remaining treatments, you can normally leave after one hour and pass urine at home
  • there is no risk of contamination with the anti-cancer drug when you get home
  • you should drink plenty of fluids (two to three litres) for the first few days after the treatment
  • we usually repeat the procedure every week for 6 weeks; the urology staff will advise you about the need for any further, maintenance treatments

Are there any after-effects?

The possible after-effects and your risk of getting them are shown below. 

Some are self-limiting or reversible, but others are not.  We have not listed very rare after-effects (occurring in less than 1 in 250 patients) individually. The impact of these after-effects can vary a lot from patient to patient; you should ask your surgeon’s advice about the risks and their impact on you as an individual:

After-effect Risk
Some degree of bladder discomfort during the treatment  Between 1 in 2 & 1 in 10 patients 
Irritation at the tip of urethra on passing urine   Between 1 in 2 & 1 in 10 patients 
Discolouration of your urine  Between 1 in 2 & 1 in 10 patients 
Blood in your urine  Between 1 in 2 & 1 in 10 patients 
Debris in your urine  Between 1 in 2 & 1 in 10 patients 
A skin rash  Between 1 in 10 & 1 in 50 patients 
Failure to complete the course of treatment because of bladder discomfort  Between 1 in 10 & 1 in 50 patients 
Infection in your urine  Between 1 in 10 & 1 in 50 patients 
Stricture (narrowing) of the urethra (water pipe) following repeated use of a catheter  Between 1 in 10 & 1 in 50 patients 
Severe pain on instillation which persists after you have emptied your bladder  Between 1 in 50 & 1 in 250 patients 
An allergic reaction to the instilled drug, resulting in you having  to stop the treatment  Between 1 in 50 & 1 in 250 patients 
Long-term shrinkage of the bladder with a reduction in your bladder capacity  Between 1 in 50 & 1 in 250 patients 

What can I expect when I get home?

  • a copy of your treatment details will be sent to your GP
  • any antibiotics or other tablets you may need will be arranged & dispensed, either from the hospital pharmacy or by your GP
  • you should always wash your hands and genitals every time you pass urine over the next few days (we also suggest that you bring a washbag with you every time you come to the hospital for treatment)
  • you should not have sex for at least 24 hours after the treatment, because you may find it quite uncomfortable
  • there is no risk of contamination with the drug when you get home
  • if you are a smoker, you should try to stop because smoking can encourage the return of bladder cancer (see below)

General information about surgical procedures

Before your procedure

Please tell a member of the medical team if you have:

  • an implanted foreign body (stent, joint replacement, pacemaker, heart valve, blood vessel graft);
  • a regular prescription for a blood thinning agent (e.g. warfarin, aspirin, clopidogrel, rivaroxaban, dabigatran);
  • a present or previous MRSA infection; or
  • a high risk of variant-CJD (e.g. if you have had a corneal transplant, a neurosurgical dural transplant or human growth hormone treatment).

Questions you may wish to ask

If you wish to learn more about what will happen, you can find a list of suggested questions called "Having An Operation" on the website of the Royal College of Surgeons of England.  You may also wish to ask your surgeon for his/her personal results and experience with this procedure.

Before you go home

We will give you advice about what to look out for when you get home.  Your surgeon or nurse will also give you details of who to contact, and how to contact them, in the event of problems.

Smoking and surgery

Since you are only having a local anaesthetic, stopping smoking will have no effect on this procedure.  Smoking can, however, cause cancers of the urinary tract and cause existing cancers to recur or progress.  We strongly advise anyone with bladder cancer to stop smoking.  For advice on stopping, you can:

Driving after any procedure

It is your responsibility to make sure you are fit to drive even after a minor surgical procedure.  You only need to contact the DVLA if your ability to drive is likely to be affected for more than three months.  If it is, you should check with your insurance company before driving again. 

What should I do with this information?

Thank you for taking the trouble to read this information.  Please let your urologist (or specialist nurse) know if you would like to have a copy for your own records. 

What sources have we used to prepare this leaflet?

This leaflet uses information from consensus panels and other evidencebased sources including:

It also follows style guidelines from: 

 Disclaimer

We have made every effort to give accurate information but there may still be errors or omissions in this leaflet.